qhd43417

Name of Target: 
ORF3a
Function: 
Forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. Up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. Induces apoptosis in cell culture. Downregulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination
Ramchandran Plot: 
File upload: 
File QHD43417.pdb
Binary Data qhd43417.pdbqt
Plain text icon conf.txt
Product: 
orf3a protein