Listof Targets

Sr. No Titlesort descending Product Name of Target Function Download
1 4wxr NS3 Helicase from HCV
2 5qj0 HCV NS5B RNA-DEPENDENT RNA POLYMERASE
3 6CRX Spike Surface Glycoprotein (S) SARS Spike Glycoprotein, Stabilized variant, two S1 CTDs in the upwards conformation: reported in Year 2018
4 6lu7 The crystal structure of COVID-19 main protease in complex with an inhibitor N3 X-ray Diffraction method based study. Downloaded from PDB
5 6nur SARS-Coronavirus NSP12 bound to NSP7 and NSP8 co-factors
6 6piv HCV NS3/4A D168A protease
7 6vsb Spike Surface Glycoprotein (S) Prefusion 2019-nCoV spike glycoprotein with a single receptor-binding domain up
8 6XQB SARS-CoV-2 RdRp/RNA complex
9 7LYN Spike Surface Glycoprotein (S) South African (B.1.351) SARS-CoV-2 spike protein variant (S-GSAS-B.1.351) in the 1-RBD-up conformation
10 7PFN Crystal Structure of a Class D Carbapenemase_K73ALY Complexed with Imipenem
11 7T9J Spike Surface Glycoprotein (S) Cryo-EM structure of the SARS-CoV-2 Omicron spike protein
12 EPI_ISL_1589734 Spike Surface Glycoprotein (S) B.1.617 Spike Protein
13 qhd43415_1 Host translation inhibitor nsp1 Inhibits host translation by interacting with the 40S ribosomal subunit.
14 qhd43415_10 Non-structural protein 10 (nsp10) Plays a pivotal role in viral transcription by stimulating both nsp14 3'-5' exoribonucleas
15 qhd43415_11 RNA-directed RNA polymerase (RdRp). Responsible for replication and transcription of the viral RNA genome.
16 qhd43415_12 Helicase (Hel) Multi-functional protein with a zinc-binding domain in N-terminus displaying RNA and DNA duplex-unwi
17 qhd43415_13 Guanine-N7 methyltransferase (ExoN). Enzyme possessing two different activities: an exoribonuclease activity acting on both ssRNA and dsR
18 qhd43415_14 Uridylate-specific endoribonuclease (NendoU). Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to
19 qhd43415_15 2'-O-methyltransferase (2'-O-MT). Methyltransferase that mediates mRNA cap 2'-O-ribose methylation to the 5'-cap structure o
20 qhd43415_2 Non-structural protein 2 (nsp2). May play a role in the modulation of host cell survival signaling pathway by interacting with host P
21 qhd43415_3 Papain-like proteinase. Responsible for the cleavages located at the N-terminus of the replicase polyprotein.
22 qhd43415_4 Non-structural protein 4 (nsp4). Participates in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for v
23 qhd43415_5 orf1a Proteinase 3CL-PRO. Cleaves the C-terminus of replicase polyprotein at 11 sites.
24 qhd43415_6 Non-structural protein 6 (nsp6). Plays a role in the initial induction of autophagosomes from host reticulum endoplasmic.
25 qhd43415_7 Non-structural protein 7 (nsp7). Forms a hexadecamer with nsp8 (8 subunits of each) that may participate in viral replication by acti
26 qhd43415_8 Non-structural protein 8 (nsp8). Forms a hexadecamer with nsp7 (8 subunits of each) that may participate in viral replication by acti
27 qhd43415_9 Non-structural protein 9 (nsp9). May participate in viral replication by acting as a ssRNA-binding protein
28 qhd43416 surface glycoprotein Surface glycoprotein (S). Spike protein S1 (residue 14-685): attaches the virion to the cell membrane by interacting with host
29 qhd43417 orf3a protein ORF3a Forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release.
30 qhd43418 envelope protein E. Plays a central role in virus morphogenesis and assembly.
31 qhd43419 membrane glycoprotein M. Component of the viral envelope that plays a central role in virus morphogenesis and assembly via it
32 qhd43420 orf6 protein ORF6. Could be a determinant of virus virulence, since, when expressed in an otherwise attenuated JHM stra
33 qhd43421 orf7a protein ORF7a. Non-structural protein which is dispensable for virus replication in cell culture.
34 qhd43422 orf8 protein ORF8
35 qhd43423 nucleocapsid phosphoprotein N. Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fund
36 qhi42199 orf10 protein ORF10 Dubious/uncertain protein.